Jonathan VAPPOU

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Associate Research Scientist, HDR, CNRS



Curriculum Vitae

  • Since Dec. 2016: Habilitation à Diriger les Recherches
  • Since Oct. 2011: Associate Research Scientist, CNRS, at Icube laboratory, Strasbourg.
  • 2007-2010: Postdoctoral Researcher, Department of Biomedical Engineering, Columbia University, New York.
  • 2004-2007: PhD Thesis, ULP, Strasbourg.
  • 2004: MS Engineering Degree, ENSPS (Engineering school), Strasbourg.
  • 2004: MS, Mechanical Engineering, ULP, Strasbourg.

Research Topics

My research activities are focused on the development and use of original medical imaging-based technologies to support new therapeutic methods. This requires a strongly multidisciplinary approach combining research fields such as Imaging, Biomechanics, Acoustics, Medical Robotics, Minimally and non-invasive surgery, and Interventional Radiology.

Keywords:

  • Magnetic Resonance and Ultrasound Elasticity Imaging/Elastography
  • Biomechanics
  • High Intensity Focused Ultrasound (HIFU) non-invasive therapy
  • MRI-guided percutaneous, minimally-invasive surgery
  • Medical and surgical robotics
  • Computer-Assisted Surgery

Research Projects

High Intensity Focused Ultrasound (HIFU) therapy on bone (UFOGUIDE project, FUI funding)

High Intensity Focused Ultrasound (HIFU) is the only non-invasive, non-ionizing method for the ablation of solid tumors. During HIFU therapy, high intensity ultrasound beams are focused within the region to be treated (e.g., tumor), and the absorption of the acoustic energy allows for localized heating of the tissue, leading to its ablation within the focal region. The UFOGUIDE project (FUI funding, 2017-2020) aims at developping a new HIFU system for treating bone tumors under MRI guidance, in collaboration with Image Guided Therapy (Pessac, France) and Axilum Robotics (Strasbourg, France).

Blood-brain barrier opening using focused ultrasound (3BOPUS project, ANR funding)

The 3BOPUS project (ANR funding) aims at developing a new low-cost system for opening the blood-brain barrier non-invasively using ultrasound. The proposed system relies on the use of a neuronavigated robotic arm in order to target the region of the brain that needs to be treated. Participating partners are CEA/Neurospin (leader), Image Guided Therapy (Pessac, France), Axilum Robotics (Strasbourg, France), and BrainTech Lab (Grenoble, U1205).

Estimating the post-mortem delay non-invasively using ultrasound (DeathOClock project, SATT Conectus funding)

Estimating the post-mortem delay (PMD) is a major challenge in Legal Medicine. Current gold standard methods are highly inaccurate and/or invasive. In this project, we are developing a new device that allows estimating the PMD non-invasively, with higher accuracy. The proposed device relies on the measurement of temperature variations inside brain tissue, using non-invasive ultrasound pulse/echo. This device is being developed in collaboration with the Institute of Legal Medicine of Strasbourg (Pr. Jean Sébastien Raul)


Magnetic Resonance Elastography for Computer-Assisted Surgery (MRE-CAS, IHU Strasbourg funding)

Surgery has undergone major changes over the past decade as a consequence of an increased use of digital technologies. Computer-Assisted Surgery is a fast-growing field that encompasses a large variety of technological developments ranging from real-time medical image-guidance to surgical simulations and medical robotics. Recent progress in medical imaging has contributed to the emergence of Computer-assisted surgery, by providing accurate anatomical measurements. However, the knowledge of physical/mechanical properties is essential since surgery relies precisely on the interaction between a tool and an organ. The realism and the accuracy of all numerical models are unavoidably related to the knowledge of such physical interactions. Recent progress in 3D anatomical modelling contrasts with the critical lack of tools that would provide physical properties of organs in vivo. The general objective of this project is to overcome this critical limitation by developing a Magnetic-Resonance-Elastography (MRE)-based method that will provide novel, quantitative biomechanical in vivo data. The objectives of this project are (1) To couple this method and resulting measurements with surgical simulators and medical robots to improve their realism, and (2) To integrate MRE in an interventional setup in order to help to the targeting, monitoring and follow-up of minimally-invasive procedures.

Publications in peer-reviewed international journals

J Vappou, P Bour, F Marquet, V Ozenne, B Quesson, MR-ARFI-based method for the quantitative measurement of tissue elasticity: application for monitoring HIFU therapy, Physics in Medicine and Biology, 2018 63(9)

M Bilasse, S Chatelin, G Altmeyer, A Marouf, J Vappou, I Charpentier, A 2D finite element model for shear wave propagation in biological soft tissues: application to Magnetic Resonance Elastography, International journal for numerical methods in biomedical engineering, e3102, 2018

F. Bing, J. Vappou, La radiologie interventionnelle minimise les risques chirurgicaux, Biofutur P30-31, 2017

N. Corbin, É. Breton, M. de Mathelin, J. Vappou, K-space data processing for magnetic resonance elastography (MRE), Magnetic Resonance Materials in Physics, Biology and Medicine, 2017 30; 203-213

S. Chatelin, I. Charpentier, N. Corbin, L. Meylheuc, J. Vappou, An automatic differentiation-based gradient method for shear wave inversion in magnetic resonance elastography: specific application in fibrous soft tissues, Physics in Medicine and Biology, pages 5000-5019, 2016

N Corbin, J Vappou, E Breton, Q Boehler, L Barbé, P. Renaud, and M. de Mathelin, Interventional MR elastography for MRI‐guided percutaneous procedures (2016), Magnetic Resonance in Medicine, pages 1110-1118, Volume 75.

Vappou, Y. Hou, F. Marquet, D. Shahmirzadi, J. Grondin, and E. E. Konofagou, Non-contact, ultrasound-based indentation method for measuring elastic properties of biological tissues using Harmonic Motion Imaging (2015), Physics in Medicine and Biology 60 2853-2868

J. Oudry, T. Lynch, J. Vappou, L. Sandrin and V. Miette, Comparison of four different techniques to evaluate the elastic properties of phantom in elastography: is there a gold standard, (2014) Physics in Medicine and Biology, 59 5775-5793

Khamdaeng, T., Luo, J., Vappou, J., Terdtoon, P., Konofagou, E.E., Arterial stiffness identification of the human carotid artery using the stress-strain relationship in vivo, (2012) Ultrasonics, 52 (3), pp. 402-411.

Chatelin, S., Vappou, J., Roth, S., Raul, J.S., Willinger, R. Towards child versus adult brain mechanical properties (2012) Journal of the Mechanical Behavior of Biomedical Materials, 6, pp. 166-173.

Hou, G.Y., Luo, J., Marquet, F., Maleke, C., Vappou, J., Konofagou, E.E. Performance assessment of HIFU lesion detection by harmonic motion imaging for focused ultrasound (HMIFU): A 3-D finite-element-based framework with experimental validation (2011) Ultrasound in Medicine and Biology, 37 (12), pp. 2013-2027.

Vappou, J., Luo, J., Okajima, K., Di Tullio, M., Konofagou, E.E. Non-invasive measurement of local pulse pressure by pulse wave-based ultrasound manometry (PWUM) (2011) Physiological Measurement, 32 (10), pp. 1653-1662.

Vappou, J., Luo, J., Okajima, K., Di Tullio, M., Konofagou, E. Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry (2011) Artery Research, 5 (2), pp. 65-71.

Vappou, J., Luo, J., Konofagou, E.E., Pulse Wave Imaging for noninvasive and quantitative measurement of arterial stiffness in vivo, American Journal of Hypertension, 2010, Apr;23(4):393-8.

Danpinid, A., Luo, J., Vappou, J., Terdtoon, P., Konofagou, E.E., In Vivo Characterization of the Aortic wall Stress-Strain Relationship using a noninvasive Ultrasound-based method, Ultrasonics, 2010 Jun;50(7):654-65.

Vappou, J., Maleke, C. & Konofagou, E.E. Quantitative viscoelastic parameters measured by harmonic motion imaging, Physics In Medicine And Biology, 2009, Vol. 54(11), pp. 3579-3594

Oudry J., Vappou, J., Choquet, P., Willinger, R., Sandrin, L., Constantinesco, A. Ultrasound-based Transient Elastography compared to Magnetic Resonance Elastography in soft tissue-mimicking gels, Physics In Medicine And Biology, 2009, Vol. 54(22), 6979-6990.

Roth, S., Vappou, J., Raul, J.S. & Willinger, R. Child head injury criteria investigation through numerical simulation of real world trauma, Computer Methods and Programs In Biomedicine, 2009, Vol. 93(1), pp. 32-45

Vappou, J., Breton, E., Choquet, P., Willinger, R. & Constantinesco, A. Assessment of in vivo and post-mortem mechanical behavior of brain tissue using magnetic resonance elastography, Journal of Biomechanics, 2008, Vol. 41(14), pp. 2954-2959

Vappou, J., Breton, E., Choquet, P., Goetz, C., Willinger, R. & Constantinesco, A. Magnetic resonance elastography compared with rotational rheometry for in vitro brain tissue viscoelasticity measurement, Magnetic Resonance Materials in Physics Biology And Medicine, 2007, Vol. 20(5-6), pp. 273-278

Vappou, J., Willinger, R., Breton, E., Choquet, R., Goetz, C. & Constantinesco, A. Dynamic viscoelastic shear properties of soft matter by magnetic resonance elastography using a low-field dedicated system, Journal Of Rheology, 2006, Vol. 50(4), pp. 531-541

Teaching

  • Introduction to Biomechanics, TIC-Santé Telecom Physique Strasbourg 1A
  • Continuum Mechanics, Biomechanics and Rheology, TIC-Santé Telecom Physique Strasbourg 2A